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The high affinity of UCB for neuronal membranes causes a conformational change in the NMDA receptor, resulting in an open and activated NMDA receptor-ion channel complex [19]

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As the elimination of MEK via inhalation constitutes only 5 to 10% of the total loss (Cushny, 1910), these rates should be multiplied by factors of 10-20

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Lapierre LR, Hansen M (2012)

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JAMA 302(13):14291436

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